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Porphyria. Oxazepam is considered to be unsafe in patients with porphyria although there is conflicting experimental evidence of porphyrinogenicity.
Renal impairment. Pharmacokinetic studies suggest that, in general, the dosage of oxazepam does not need adjusting in patients with renal impairment.
buy alepam australia Thyroid disorders. There was a reduction in half-life and an increase in the apparent oral clearance of oxazepam in 7 hyperthyroid patients. In 6 hypothyroid patients there was no overall change in oxazepam elimination, although 5 of the 6 complained of drowsiness despite a relatively low dose (15 mg).
As for Diazepam.
buy alepam australia is well absorbed from the gastrointestinal tract and reaches peak plasma concentrations about 2 hours after ingestion. It crosses the placenta and has been detected in breast milk. Oxazepam is about 85 to 97% bound to plasma proteins and has been reported to have an elimination half-life ranging from about 3 to 21 hours. It is largely metabolised to the inactive glucuronide which is excreted in the urine.